Clinical Trial Manager

Join Immatics and shape the future of cancer immunotherapy; one patient at a time!
Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.
Why Join Us?
Innovative Environment: Help to pioneer advancements in cancer immunotherapy.
Collaborative Culture: Be part of a diverse team dedicated to your professional growth.
Global Impact: Contribute to therapies that make a lasting impact on patients globally.
Role Overview
We are seeking a Clinical Trial Manager (CTM) to support our U.S. Clinical Operations team. The CTM will oversee site management, monitoring oversight, and clinical trial operations activities to ensure compliance with GCP, regulatory requirements, and company SOPs. In this role, you will work closely with cross-functional teams and clinical sites to drive study execution, site engagement, and operational excellence across clinical trials.
Reports to: Associate Director, Team Lead Site Operations
Location: Fully Remote
Salary Range: $130,000 - $150,000
Basic Qualifications
Bachelor’s degree in life sciences, nursing, or a related field
2+ years of experience in on-site clinical monitoring and 2+ years of Clinical Trial Manager experience within the pharmaceutical or biotechnology industry
Strong knowledge of ICH-GCP, FDA, EMA, and applicable clinical trial regulations
Demonstrated experience managing clinical trial sites, monitoring activities, and regulatory documentation
Proficiency with clinical trial systems and tools (e.g., CTMS, eTMF, Microsoft Office)
Preferred Qualifications
Experience in oncology clinical trials or related therapeutic areas
Advanced ability to manage complex clinical operations processes and drive operational improvements
Experience leading training initiatives for CRAs and clinical trial sites
Demonstrated ability to drive quality, efficiency, and milestone achievement in fast-paced clinical environments
Experience contributing to process harmonization, innovation, and continuous improvement initiatives
Strong presentation, organizational, and cross-functional stakeholder management skills
In This Role You Will
Partner with Clinical Operations leadership to support clinical trial execution and monitoring activities in alignment with project goals
Lead site feasibility, selection, initiation, and greenlight activities for clinical trial sites
Develop and maintain study-specific operational plans, training materials, and monitoring documentation
Oversee site management activities, including site engagement, regulatory submissions, and monitoring oversight
Review trial progress, patient recruitment, and data quality metrics, and implement actions to support study objectives
Provide guidance and oversight to CRAs, including trip report review and training support
Manage protocol and GCP deviations and contribute to continuous improvement of clinical operations processes and procedures
Travel required: up to 50% travel required, domestically and internationally.
Qualified candidates will participate in a structured interview process, which includes:
An initial recruiter phone screen (conducted via video)
A recruiter-facilitated introduction and interview with the hiring leader and key stakeholders (via video)
A final-stage interview, which may include an in-person meeting at our U.S. Headquarters in Houston, TX
What do we offer?
At Immatics, we believe in investing in our team’s health, safety and well-being. Here’s what you can expect if you join Immatics
Comprehensive Benefits:
Competitive rates for Health, Dental, and Vision Insurance
4 weeks of vacation, granted up front each year and prorated for first and last year of employment.
12 company paid holidays
7 days of sick time
100% employer-paid life insurance up to at 1x annual salary, up to one hundred thousand dollars
100% employer-paid short- and long-Term disability coverage
401(k) with immediate eligibility and company match. The company will match 100% of your contributions up to 3% of your base salary for the first two years of employment, 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment.
Partially paid parental leave for eligible employees.
Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance.
Equal Employment Opportunity
We are an equal opportunity employer and are committed to building a diverse and inclusive workplace. We consider all qualified applicants for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, national origin, ancestry, age, marital status, disability, genetic information, veteran status, or any other status protected by applicable law.
Reasonable Accommodations
We are committed to providing reasonable accommodations to individuals with disabilities and to applicants with sincerely held religious beliefs, practices, or observances. If you require assistance or accommodation during the application or interview process, please contact us at RecruitingUS@immatics.com.
Work Authorization
Applicants must be authorized to work in the United States without the need for current or future sponsorship.
Pre-Employment Requirements
Employment is contingent upon successful completion of a background check, reference checks and pre-employment drug screening, where permitted by applicable law. For certain roles, additional screenings such as a credit check or motor vehicle record review may be required, where job-related and consistent with business necessity.

Work arrangement
No