Scientist I/II, In Vivo Pharmacology – Immuno-oncology

Our expanding In Vivo Pharmacology group in South San Francisco, CA has an opening for a motivated tumor biologist who is dedicated to the discovery and development of innovative therapeutics, both small molecule and biologics, with a focus on immuno-oncology. The Scientist I will perform tumor efficacy and PK/PD studies and provide pharmacology support to innovative cancer drug development. The scientist will work collaboratively in a project team setting with biology, medicinal chemistry, biologics, and DMPK scientists to advance oncology programs through the R&D pipeline.
Key Accountabilities/Core Job Responsibilities:
Design, execute and optimize efficacy/PK/PD studies utilizing tumor models in both immunocompetent and immunocompromised mice.
Understand and adhere to IACUC protocols regarding animal welfare and handling.
Data analyses and presentation of pharmacodynamic/disease results, and work across discovery teams to integrate efficient workflows for cross-functional collaborations.
Commitment to scientific rigor, high data quality and careful documentation.
Required Qualifications:
Scientist I: MS with 2+ years of experience, or BS with 5+ years of experience
Scientist II: MS with 5+ years of experience, or BS with 7+ years of experience
Degree in cancer biology, immunology, pharmacology, or a related with extensive hands-on skills of in vivo tumor model execution; preferably in a pharmaceutical or biotech industry setting.
Proficient hands-on experience with in vivo pharmacodynamic and tumor models, including anesthetization, biological sample collection (blood, spleen, lymph node, etc.), cell/drug administration via different routes/sites (SC, IP, PO, IV), and tumor volume measurement.
Technical experience and knowledge in tissue culture and immune cell isolation from lymphoid tissue are desired.
Knowledge of PK/PD relationships, flow cytometry, and other standard molecular and cellular biology assays (MSD, ELISA, etc.) are advantages.
Understanding of in vivo optical imaging approaches and familiarity with instrumentation (e.g. IVIS instrument) is also an advantage.
Must be proactive and able to manage multiple responsibilities, adapt to changing priorities and meet deadlines in a fast-paced environment.
Excellent verbal and written communication skills and the willingness to work and build strong relationships with peers in a multidisciplinary team are essential.
Flexibility and motivation to learn techniques and accomplish goals outside those stated above.

Employment type
Full-time

Work arrangement
No