Senior Scientist, Materials Development

We are seeking a highly innovative Materials Scientist with deep expertise in non-traditional solid-form strategies for beyond Rule-of-5 (bRo5) molecules, including PROTACs, RIPTACs, and molecular glues. This role will support the design of advanced solid form screening approaches, amorphous solid dispersion (ASD) formulations, predictive mathematical models. The position is based in Groton, CT (USA).
Role Responsibilities:
Conduct advanced solid-state characterization of large bRo5 molecules of pharmaceutical relevance.
Apply novel crystallization techniques to recrystallize bRo5 molecules.
Support multidisciplinary project teams and collaborate with colleagues to define and implement crystallization, polymorph, salt, and co-crystal screening activities according to project timelines.
Collaborate with colleagues in Medicinal Chemistry, Formulation and Biopharmaceutics to define and implement screening and characterization strategies consistent with solid form selection for clinical studies.
Solve scientific problems using contemporary Materials Science experimental techniques.
Contribute to the development of new scientific approaches and knowledge within the Materials Science organization.
Ensure contemporaneous and accurate entries are made in the electronic laboratory notebook system according to accepted good practice.
Master’s Degree (MS) with 2+ years of experience or a PhD in pharmaceutical science, chemistry, chemical engineering, or related field.
Experience in pharmaceutical solid state characterization techniques (such as x-ray powder diffraction, polarized light microscopy, differential scanning calorimetry, thermogravimetric analysis, spectroscopy, etc.). Strong data analysis and interpretation skills.
Experience and understanding of infrared spectroscopy (FTIR, NIR, FT-Raman) and/or SSNMR.
Experience with solving Materials Science problems related to large molecules, e.g., solid state chemistry and particle characterization using experimental approaches and team collaboration.
Experience with amorphous solid dispersion strategies and ability to develop innovative solid form screening strategies.
Understanding of physical, analytical, and organic chemistry.
Good organizational skills, the ability to work independently, and excellent oral and written communication skills are required.
Experience in mathematical modeling.

Employment type
Full-time

Work arrangement
No