VP, Scientific IT Business Partner

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.
Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).
Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.
The Vice President, Scientific IT Business Partner will lead Madrigal’s Scientific IT Business Partnership, supporting the company’s Research & Development and Technical Operations organizations. This role will serve as the senior IT partner to the R&D and TechOps executive leadership teams, translating functional strategy into technology roadmaps, portfolio priorities, operating capabilities, and delivery outcomes.
As Madrigal continues to grow, the technology needs across R&D and TechOps are becoming more complex, interconnected, and critical to the company’s ability to execute. This leader will help mature how IT supports the scientific value chain, bringing both domains together with a breadth to lead across an interconnected landscape, ensuring the right systems, data, integrations, processes, partners, and internal capabilities are in place to support clinical development, regulatory progression, quality, manufacturing, supply, and continued operational scale.
This is a senior IT leadership role that requires deep life sciences technology experience, strong executive influence, and the ability to operate across strategy and execution. The VP will own the Scientific IT portfolio, budget, roadmap, and business partnership model, while working closely with Data, AI, Cybersecurity, Enterprise Architecture, Infrastructure, PMO, and IT Compliance to ensure solutions are scalable, compliant, secure, and aligned to enterprise standards.
A key part of this IT leadership role will be supporting R&D and TechOps as those functions build more internal business capability and reduce reliance on external partners. As functional ownership moves further in-house, this leader will ensure the technology roadmap, systems, data, integrations, governance, and support model evolve alongside the business. The VP will partner with R&D and TechOps leaders to anticipate how those shifts affect process ownership, compliance needs, decision-making, and operating rhythms, and translate those needs into practical technology plans.
Key Responsibilities
Scientific IT Strategy & Executive Partnership
Serve as the senior IT business partner for Madrigal’s R&D and TechOps organizations, building trusted relationships with the respective ELT members and their leadership teams.
Translate R&D and TechOps business strategies into multi-year technology roadmaps, investment priorities, and portfolio plans.
Develop sufficient digital breadth across the scientific value chain to anticipate cross functional implications and ensure technology decisions made within one domain support the broader R&D and TechOps strategy.
Provide strategic technology guidance across the scientific value chain, including clinical development, regulatory, quality, manufacturing, supply chain, CMC, and related scientific business capabilities.Partner with business leaders to identify opportunities where technology, data, automation, and AI can improve speed, quality, compliance, visibility, and decision-making.
Represent R&D and TechOps needs within ITLT and enterprise governance forums, ensuring scientific priorities are visible, well-understood, and appropriately sequenced.
Navigate competing priorities across R&D and TechOps, facilitating balanced recommendations that align with enterprise and corporate objectives.
Portfolio, Roadmap & Investment Leadership
Own the Scientific IT portfolio across R&D and TechOps, including roadmap development, investment planning, prioritization, and value realization.
Maintain an integrated view of technology needs, investments, dependencies, and risks across the scientific value chain.Partner with PMO and IT leadership to ensure initiatives are appropriately scoped, sequenced, resourced, governed, and delivered.
Develop clear business cases for technology investments, including expected value, risk, implementation approach, resource needs, and long-term operating implications.
Make start / stop / sequence recommendations for Scientific IT initiatives based on business value, risk, capacity, dependencies, and strategic alignment.
Ensure Scientific IT roadmaps are realistic, integrated, and aligned with enterprise architecture, data strategy, cybersecurity, infrastructure, and compliance expectations.
Provide executive-level visibility into portfolio health, delivery risks, resource constraints, and key decisions needed to keep work moving.
R&D Technology Leadership
Lead IT partnership and delivery for R&D functions, with near-term emphasis on Clinical Development and Regulatory capabilities.
Support the continued buildout of Madrigal’s R&D technology landscape, including systems and capabilities that enable clinical execution, regulatory operations, scientific collaboration, data flow, inspection readiness, and decision-making.
Bring strong working knowledge across R&D technology domains, while leveraging and growting internal and external subject matter expertise where deeper specialization is required.
Partner with R&D leaders to identify technology needs across the development lifecycle and translate those needs into practical, scalable solutions.
Connect technology decisions across Clinical, Regulatory, Safety, Data and other R&D capabilities to reduce fragmentation and create an integrated scientific technology landscape.
Ensure R&D technology investments support clinical operations, regulatory milestones, data quality, compliance, and business agility.
Strengthen internal ownership of critical R&D technology capabilities that require business context, continuity, and close alignment with scientific priorities.
TechOps Technology Leadership
Lead IT partnership and delivery for TechOps functions, including CMC, Quality, Manufacturing, Supply Chain, and related operational capabilities.
Apply broad understanding of the TechOps technology landscape while drawing on specialized expertise across Quality, Manufacturing, Supply Chain, CMC and other domains as needed.
Build trusted relationships with TechOps leaders to understand business priorities, operational risks, external partner dependencies, and technology needs.
Help mature the TechOps technology roadmap as Madrigal scales its manufacturing, quality, supply, and product lifecycle capabilities.Provide strategic oversight of across systems and capabilities such as QMS, LIMS, ERP, serialization, supply planning, quality documents, deviation / CAPA / change control, batch records, external manufacturing portals, and related manufacturing or quality systems.
Identify opportunities to improve visibility, data flow, process consistency, and decision-making across internal teams and external manufacturing / supply partners.