Director, Clinical Practice Liaison Team- East Region

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.
Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).
Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.
Role Summary:
The Director, Clinical Practice Liaison (CPL) is a senior leadership role with broader strategic accountability for the CPL function (part of the Field Medical Team at Madrigal) within a defined U.S. region and therapeutic area. This individual will play a pivotal role in shaping the vision, direction, and performance of the CPL team, ensuring the team aligns with and advances the company’s overarching medical strategy, adheres to regulatory and internal policies, and maximizes scientific impact for both internal and external stakeholders.
This position will collaborate closely and compliantly with cross-functional colleagues (e.g., Marketing, Sales, Market Access, Clinical Operations, HQ Medical Affairs) and external partners, including healthcare decision-makers and other relevant stakeholders, serving as a key liaison to drive strategic initiatives and influence medical and business outcomes.
The position reports to the Executive Director, Field Medical and is a field-based position with travel required within assigned territory.
All incumbents are responsible for following applicable Medical Affairs & Madrigal policies and procedures and are compliant with applicable policies, procedures, and regulations. Strong understanding of US regulations and compliance is required.
Please note: Candidates may reside anywhere within the Eastern United States.
Key Responsibilities and Primary Activities:
CPL Team Scientific & Clinical Education
Support and help shape the regional strategy for the CPL team to deliver unbiased, evidence-based education on MASH, ensuring CPLs address identified gaps in knowledge and clinical implementation
Promote consistent and high-quality communication of clinical practice guidelines and real-world data related to MASH diagnosis, risk stratification, and patient management
Maintain strong working knowledge of MASH Non-Invasive Testing (NITs), treatment paradigms, and clinical protocols across the liver/metabolic spectrum, while providing scientific guidance to the team
CPL Team Practice Engagement & Enablement
Support the Executive Director in the oversight of practice engagement, ensuring CPLs effectively support implementation of MASH care pathways
Support adoption of guideline-based approaches, payer-aligned workflows, and quality-driven practice standards across the region.
Ensure accuracy and compliance in CPL responses to unsolicited inquiries, reinforcing regulatory expectations
Team Leadership & Development
Recruit, coach, and manage performance of regional CPLs
Foster continuous development through mentoring, structured training, and scientific upskilling
Ensure CPL activities align with strategic objectives and tactical plans, supporting consistency and quality in execution
Medical Strategy Execution
Execute regional field medical strategies in alignment with national direction
Translate national medical objectives into actionable, regionally tailored field activities
Partner with HQ Medical Affairs and cross-functional leaders to integrate meaningful field insights into medical planning
Clinical Trial Support
Collaborate with Clinical Operations to support successful study execution based on regional site and practice needs
Identify potential research sites or practice barriers informed by field insights
Cross-Functional Collaboration
Act as a regional medical point-of-contact, partnering across Medical Affairs, Sales, Marketing, Market Access, and Clinical Operations to maintain alignment and address clinical or strategic needs
Serve as a conduit for HQ Medical Affairs initiatives, ensuring clear communication and coordinated execution
Contribute to launch readiness and lifecycle management activities, ensuring CPL efforts support national and regional priorities
Represent Madrigal at scientific meetings, supporting CPL engagement and ensuring compliant scientific exchange and insight collection
Insight Gathering & Strategic Feedback
Synthesize, prioritize, and elevate regionally derived insights to inform medical strategy, evidence-generation planning, and educational needs
Keep abreast of regional analysis of emerging clinical trends and barriers to care, providing strategic recommendations for internal planning
Ensure structured, compliant insight reporting across the CPL team
Compliance & Professional Standards
Adhere strictly to all applicable company and regulatory policies, including FDA and industry guidelines for non-promotional medical engagements
Ensure thorough documentation and accountability for all scientific interactions.
Maintain a strong understanding of US regulations and compliance
Travel Requirement
Ability to travel from 25-70% including support of scientific meetings over weekends
Required Qualifications, Skills & Experience:
Advanced degree in a scientific or healthcare discipline (MD, PharmD, PhD, DNP, etc.)
Minimum 5 years of Medical Affairs experience, including at least 3 years as an MSL or equivalent (translatable clinical practice experience will be considered)
Minimum 3 years of people management experience or formal leadership development participation
In-depth knowledge of clinical medicine and medical research
Proven ability to understand, communicate, and translate complex scientific information
Strong knowledge of U.S. healthcare system, FDA regulations, and medical affairs compliance standards
Demonstrated cross-functional collaboration, project exe