Senior Scientist I, Peptide Purification

Reporting:
Head of Chemistry
Description:
We are seeking a highly motivated Senior Scientist I, Peptide Purification to join Mariana's Discovery Chemistry organization. The successful candidate will play a key role in advancing peptide-based radiopharmaceutical programs through the development and execution of purification strategies to support discovery and candidate optimization efforts.
This position is a laboratory-based role that combines scientific expertise, hands-on execution, and technical leadership. The successful candidate will work closely with cross-functional teams, provide mentorship and guidance to junior scientists, and contribute to the advancement of innovative therapeutics in a fast-paced and collaborative environment.
Illustrative Breadth of Responsibilities:
Develop, optimize, and execute purification workflows for peptide, peptidomimetic, and related therapeutic modalities using preparative and analytical chromatographic techniques.
Purify and characterize compounds using HPLC, UPLC, LC-MS, and other analytical technologies to support discovery projects.
Independently troubleshoot complex purification and analytical challenges.
Serve as a technical resource within the purification function by providing scientific guidance, mentorship, and training to junior scientists and research associates.
Partner closely with medicinal chemistry, biology, radiochemistry, DMPK, and CMC colleagues to advance programs from discovery through development candidate selection.
Develop and transfer purification and analytical methods to support evolving project needs and program progression.
Evaluate and implement new purification technologies, instrumentation, and workflows to enhance scientific capabilities and operational efficiency.
Maintain and operate purification and analytical instrumentation.
Communicate scientific findings through electronic laboratory notebooks, technical reports, presentations, and project team discussions.
Maintain compliance with laboratory safety, documentation, and data integrity standards.
Requirements/Skills:
BS/MS in Chemistry or a related scientific discipline with 4+ years of relevant industry experience.
Hands-on experience in peptide purification and analytical characterization in a pharmaceutical, biotechnology, or drug discovery setting.
Expertise in preparative and analytical chromatography, including HPLC, UPLC, and LC-MS.
Experience developing, optimizing, and troubleshooting purification workflows for peptides and related modalities.
Demonstrated ability to independently design experiments, interpret data, and solve complex technical problems.
Proven ability to mentor and train scientists while providing technical leadership across project teams.
Strong organizational, communication, and collaboration skills.
Ability to prioritize multiple activities and deliver high-quality results in a fast-paced research environment.
Experience with additional analytical techniques such as HRMS, MALDI-TOF, SFC, NMR, CD, FT-IR, or related methods is preferred.
Mariana Oncology’s Principles
Building a Legacy
Execution Excellence
Courage of our Convictions
Mariana Oncology Compensation Summary:
The salary for this position is expected to range between $93,800 and $160,800 per year. Your compensation will also include a performance-based cash incentive.
The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and will be reviewed periodically upon joining Mariana Oncology. Mariana may change the published salary range based on company and market factors.

Employment type
Full-Time

Work arrangement
No