Senior Computational Biologist I, Center for Molecular Oncology

About Us:
The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe.
Exciting Opportunity at MSK: The Cell-Free DNA (cfDNA) Informatics Team within MSK's Center for Molecular Oncology is seeking a Senior Computational Biologist to develop and apply computational methods for liquid biopsy, clonal hematopoiesis, and translational cancer genomics research. This role will support analyses using MSK-ACCESS, CMO-CH, and related sequencing platforms while collaborating closely with clinical, laboratory, and computational teams.
Role Overview:
Analyze and interpret next-generation sequencing data from MSK-ACCESS, CMO-CH, and related assays
Lead computational analyses of ctDNA, clonal hematopoiesis, treatment response, and clinical outcomes data
Develop, automate, and maintain scalable, reproducible genomic analysis workflows
Build statistical and predictive models integrating genomic and clinical datasets
Collaborate with investigators across computational, laboratory, and clinical research teams
Contribute to manuscripts, grants, presentations, and translational research initiatives
Key Qualifications:
Master's degree with relevant experience or PhD in Computational Biology, Bioinformatics, Statistics, Computer Science, or a related field
Strong programming skills in Python and/or R
Experience analyzing NGS or large-scale genomic datasets
Experience with workflow management systems such as Nextflow, Snakemake, CWL, or WDL
Experience working in Linux, HPC, and/or cloud environments
Proficiency with Git/GitHub and container technologies such as
Docker or Apptainer/Singularity
Strong statistical analysis and scientific communication skills
Core Skills:
Independent problem-solving and scientific rigor
Experience developing scalable and reproducible computational solutions
Strong collaboration and communication skills across multidisciplinary teams
Ability to manage multiple research projects in a fast-paced environment
Interest in leveraging emerging technologies, including AI-assisted tools, to enhance research productivity
Additional Information:
Schedule: Monday-Friday, 9-5 Hybrid
Location: 323 E. 61 Street, NYC
Reporting to: Senior Manager
Helpful Links:
Compensation Philosophy
Benefits
Pay Range: $114,000.00 - $182,400.00
FSLA Status: Exempt
Closing:
At MSK, we believe in fair, competitive pay that reflects your job, experience, and skills.
MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.
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