Principal Scientist I - In vivo Preclinical Development

The Principal Scientist, In Vivo Preclinical Development will play a key role in the pre-clinical team generating IND-enabling data for selection of targeted lipid nanoparticle (tLNP) drug development candidates for various indications, including autoimmune disorders. The individual will serve as a lead scientist developing, executing and communicating novel bioanalytical development strategies that achieve project specific and therapeutic modality development goals.
Designs, optimizes, executes, and troubleshoots in vivo animal studies and bioanalytical endpoints supporting these in vivo studies.
Develops protein detection assays via multiple means including flow cytometry, ELISA, and derivative technologies.
Develops robust assays for characterization of immune parameters such as phenotyping and receptor expression, cytokine expression profiling in blood and tissues from preclinical animal studies or in vitro experiments.
Coordinates with contract research organizations (CROs) and/or collaborative research teams for the purpose of executing bioanalytical assays required for in vivo screening activities.
Maintains good laboratory practice-like activities including ALCOA+ online laboratory notebooks, instrument and reagent qualification, and documentation.
Primary author and reviewer of publications, presentations and study reports/regulatory documents.
Works cross-functionally with other Research, CMC, Clinical and/or Regulatory functions to align the product strategy with program, portfolio, and corporate goals.
Present data (written and oral) and participate in project team meetings and cross-departmental team meetings.
BS or equivalent education and extensive, typically 14+ years of experience; MS or equivalent education with typically 12+ years of experience; PhD with typically 6+ years of experience in area or scientific area of discipline.
Demonstrated proficiency with complex multi-color flow cytometry panel development and experience in phenotypic analysis of multiple immune cell populations and markers of activation/exhaustion.
Experience in data analysis software including FlowJo, CellEngine, GraphPad Prism and Tableau.
Experience in molecular biology techniques such as ddPCR or Luminex/MSD-based assays.
Demonstrated ability to function as a principle investigator, generating original technical ideas and research or development strategies.
Demonstrate creative 'out of the box' thinking to solve difficult technical problems and champion new technologies to achieve project goals.
Recognized and sought out as an expert in his/her discipline within the company and possibly externally.
Experienced and demonstrated success as primary author of publications, presentations, regulatory documents and/or primary inventor of patents.
Demonstrated scientific communication and presentation skills by presenting at leading scientific conferences.

Employment type
Full-time

Work arrangement
No