Senior Clinical Project Manager, CNS - 176704

Piper Companies is seeking a Senior Clinical Project Manager, CNS to join a leading global Clinical Research Organization supporting innovative neuroscience and central nervous system clinical trials for a fully remote, permanent position. The Clinical Project Manager, CNS will provide end-to-end oversight of clinical studies focused on neurological and psychiatric indications, ensuring projects are delivered on time, within budget, and in compliance with regulatory requirements across multiple sites and regions.
Responsibilities for the Senior Clinical Project Manager, CNS:
Lead the operational execution of CNS clinical trials, overseeing timelines, budgets, study deliverables, vendor performance, and cross-functional collaboration from start-up through closeout.
Partner with Clinical Operations, Regulatory, Medical, Biometrics, Data Management, Pharmacovigilance, and external stakeholders to ensure successful study conduct and achievement of project milestones.
Manage investigator sites, patient enrollment initiatives, site activation activities, training programs, and retention strategies to support recruitment goals within neuroscience studies.
Monitor study progress, risks, quality metrics, and financial performance, implementing mitigation plans, managing scope changes, and communicating key updates to sponsors and internal leadership.
Ensure inspection readiness through proper oversight of eTMF documentation, investigational product management, safety reporting, GCP compliance, and audit preparedness activities.
Qualifications for the Senior Clinical Project Manager, CNS:
Bachelor's degree in Life Sciences, Nursing, Pharmacy, or a related scientific discipline.
5+ years of clinical research experience with at least 2 years of project management experience within a CRO, biotech, or pharmaceutical environment.
Previous experience managing CNS/neuroscience clinical trials, including indications such as Alzheimer's disease, Parkinson's disease, epilepsy, multiple sclerosis, depression, schizophrenia, or other neurological disorders.
Strong knowledge of ICH-GCP guidelines, global clinical trial regulations, study budgeting, forecasting, and vendor oversight.
Experience utilizing CTMS, eTMF platforms, EDC systems, and other clinical trial management technologies.
Excellent communication, leadership, organizational, and stakeholder management skills with the ability to oversee complex global or multi-country studies.
Compensation for the Senior Clinical Project Manager, CNS:
Salary Range: $170,000-$200,000/year (USD)
Comprehensive Benefits: Medical, Dental, Vision, sick leave if required by law, 401(k), paid time off, and additional employee wellness programs.
This job opens for applications on 10/16/26. Applications for this job will be accepted for at least 30 days from the posting date.
Keywords: CNS, neuroscience, neurology, psychiatry, Alzheimer's disease, Parkinson's disease, epilepsy, multiple sclerosis, depression, schizophrenia, clinical research, clinical trials, CRO, project management, clinical operations, vendor management, study start-up, patient recruitment, site management, CTMS, eTMF, EDC, ICH-GCP, regulatory compliance, pharmacovigilance, data management, risk management, study budgeting, forecasting, audit readiness, global trials, biotechnology, pharmaceutical, clinical development, investigational product, site activation, study oversight.

Work arrangement
Yes