Principal Research Scientist I, siRNA Platform Automation

AbbVie’s Biotherapeutics and Genetic Medicine (BGM) department is seeking a highly motivated Principal Research Scientist to join our expanding siRNA team. In this role, you will partner with genetic medicine teams to establish a high-throughput siRNA screening platform that advances pipeline innovation through next-generation delivery modalities and supports the discovery of therapeutic leads across multiple disease areas.
Responsibilities:
Establish and implement a high-throughput siRNA screening platform using automated liquid-handling systems.
Serve as a subject matter expert in siRNA screening experimental design, execution, and data interpretation.
Lead research efforts and mentor scientists to advance siRNA optimization, including sequence design and novel chemical modifications, across multiple programs.
Generate new scientific hypotheses and proposals, improve existing screening workflows, and evaluate emerging technologies in the siRNA field.
Communicate clearly and effectively with internal siRNA teams and cross-functional collaborators to identify needs and support platform enhancement and program advancement.
Manage and develop a team of at least 2-3 scientists, providing technical guidance, mentorship, and day-to-day leadership to support program goals.
BS, MS, or PhD in Molecular Biology, Biochemistry, Chemical Biology, or a related field, with typically 6+ years (PhD), 12+ years (MS), or 14+ years (BS) of relevant experience in biotech or pharma.
Proven track record in siRNA design, in vitro screening, and potency assays with experience using automated high-throughput platforms (e.g., Hamilton, Tecan).
Experience with assays including, but not limited to, qRT-PCR, ELISA, and flow cytometry.
Demonstrated experience in cell culture, including the maintenance of diverse cell lines.
Prior experience leading siRNA platform initiatives or portfolio programs.
Exceptional interpersonal skills and the ability to build productive working relationships with diverse internal teams and external collaborators.
Strong track record of presenting complex scientific data to internal and external stakeholders.
Experience in animal study design and downstream assays to evaluate genetic medicines is a plus.
Prior people management experience is a plus.

Employment type
Full-time

Work arrangement
No