Consultant, Chemistry

Job Description: Consultant, Chemistry
Location: Remote
Company: OS Therapeutics Inc., a Delaware corporation (“OS Tx”)
Application Process
To apply, please submit your resume and a brief cover letter outlining your qualifications and interest in the role to hiring@ostherapeutics.com.
About OS Tx
OS Therapeutics is a fast-growing US biotech company build around a mission to make the impossible possible for patients facing difficult-to-treat diseases. We are pioneering next-generation therapeutics that turn breakthrough science into life-changing therapies. That vision is built on a validated scientific platform, a focused strategy with a clear development roadmap, and a team with a track record of disciplined execution. Together, they position us toward a bold ambition: bringing transformative medicines to the patients and improving lives with speed and scientific discipline.
Position Overview
OS Therapeutics is seeking a Chemistry Consultant (part-time) with industry experience in siRNA therapeutics to support our discovery and preclinical development efforts, working closely with the leadership team. Operating in a lean, fast-paced startup environment, the consultant will provide expert guidance on oligonucleotide design and optimization, review chemistry data, and advise on candidate development. This is a high-impact advisory engagement for an experienced oligonucleotide chemist who enjoys translating chemistry insights into differentiated drug candidates.
Key Responsibilities
· Advise on siRNA design and optimization, including sequence selection, chemical modifications, and conjugation strategies.
· Review and interpret chemistry and analytical data and provide recommendations to the program and leadership teams.
· Advise on candidate selection and development, including developability and readiness for preclinical studies.
· Guide work with external partners (CROs/CDMOs) on oligonucleotide synthesis, scale-up, and early CMC as needed.
Qualifications
· PhD in Chemistry (organic, medicinal, or nucleic acid chemistry preferred)
· Demonstrated industry track record in oligonucleotide therapeutics, including advancing programs to candidate nomination or IND.
· Deep expertise in oligonucleotide chemistry, including chemical modifications, conjugation, and delivery.
· Familiarity with oligonucleotide CMC, analytical characterization, and regulatory considerations.
Desired Attributes
· Hands-on, pragmatic, and resourceful—comfortable rolling up sleeves and executing.
· Strong interpersonal skills and the ability to build trust across scientific, operational, and partner ecosystems.
· High personal integrity and ability to handle confidential information with discretion.
Why Join OS Tx?
· Opportunity to shape and build a pioneering biotech company at a formative stage.
· Collaborative and innovative culture with direct exposure to scientific and corporate decision-making.
· Meaningful career growth opportunities as the company scales toward clinical development.
· Competitive compensation and benefits package (details below).
OS Tx is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

Work arrangement
Yes