Scientist II, Oligonucleotides

Who We Are
BioMarin is a leading rare disease biotechnology company focused on genetically defined conditions.
Guided by our purpose to develop medicines that make a profound impact on people’s lives, our global teams have delivered a portfolio of therapies since our founding in 1997. Our revolutionary treatments for conditions like achondroplasia (the most common form of dwarfism), PKU (phenylketonuria), CLN2, a form of Batten disease, and a number of forms of MPS (mucopolysaccharidosis) offer new possibilities for patients and families who previously had few, if any, available options. More recently, with the close of the Amicus acquisition, our portfolio has expanded to include therapies for Fabry disease and Pompe disease, expanding our ability to reach more people living with rare genetic conditions.
Our success comes from our unwavering commitment to excellence, our deep understanding of patient needs, our scientific expertise, and our world-class manufacturing capabilities. At the heart of BioMarin is a dedicated team of the brightest minds in the industry working together to deliver innovative therapies to patients and families around the world.
About Worldwide Research and Development
From research and discovery to post-market clinical development, our R&D engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases.
Scientist II, Bioconjugation Chemist Job Summary:
BioMarin is seeking a dedicated and skilled Scientist II specializing in bioconjugation chemistry to contribute to our cutting-edge research and development efforts in nucleic acid-based therapeutics. The successful candidate will be responsible for designing and synthesizing bioconjugates, including antibody-drug conjugates (ADCs), antibody-oligo conjugates (AOCs), and other complex biomolecules. This role requires a strong background in organic chemistry, bioconjugation techniques, and analytical characterization methods. This role offers a unique opportunity to be part of a dynamic team at the forefront of biotechnology innovation, working on projects that have the potential to transform patient outcomes.
Key Responsibilities:
Engage actively in project team discussions across the organization, providing subject matter expertise to support the progression of research projects and the development of new methodologies.
Work synergistically with multidisciplinary teams, including bioconjugation specialists, chemists, and biologists, to drive project success and foster a collaborative research environment.
Design and synthesize bioconjugates such as antibody-oligo conjugates (AOCs), peptide conjugates, and other complex biomolecules.
Develop and optimize conjugation methodologies and purification processes.
Characterize bioconjugates using various analytical techniques, including HPLC, LC-MS, SDS-PAGE, and spectroscopy.
Collaborate with cross-functional teams, including Biology, Pharmacology, and Process Development, to support preclinical and clinical programs.
Maintain accurate and detailed laboratory records and documentation.
Present research findings to internal teams and at scientific meetings.
Stay up-to-date with the latest advancements in bioconjugation chemistry and related fields.
Qualifications:
Ph.D. in Chemistry, Biochemistry, or a related field with a focus on bioconjugation techniques and organic synthesis.
Minimum of 3-5 years of postdoctoral experience or industry experience in bioconjugation chemistry.
Strong enthusiasm for scientific research and innovation, coupled with excellent organizational skills and the ability to manage multiple tasks and projects simultaneously.
Proven track record in designing and synthesizing bioconjugates, including AOCs and peptide conjugates.
Strong knowledge of analytical techniques for characterizing bioconjugates.