Manager, Site Reliability Engineer

Manager, Site Reliability Engineer (Hybrid in South San Francisco)
About the Role
We are seeking an experienced and hands-on Site Reliability Engineering (SRE) Manager to lead our Site Operations and infrastructure initiatives. This role is responsible for ensuring the reliability, scalability, security, and performance of our cloud infrastructure and critical applications.
The ideal candidate combines strong technical expertise with leadership experience and a passion for operational excellence. You will lead efforts across cloud infrastructure, observability, automation, networking, and platform reliability while partnering closely with engineering and product teams to support business-critical applications.
Responsibilities
Lead and manage the Site Operations / SRE function
Own cloud infrastructure architecture, operations, scalability, and optimization
Ensure high availability and reliability of production applications and services
Drive operational excellence through automation, monitoring, and incident management
Develop and maintain observability platforms including logging, metrics, alerting, and tracing
Manage Kubernetes-based infrastructure and container orchestration environments
Oversee networking, DNS, CDN, and storage infrastructure across cloud environments
Collaborate with software engineering teams to improve deployment processes, system resilience, and performance
Establish and improve CI/CD pipelines and infrastructure-as-code practices
Lead incident response, root cause analysis, and post-incident remediation efforts
Manage vendor and platform relationships where applicable
Mentor and develop SRE / Site Operations engineers and foster a culture of reliability and continuous improvement
Define and implement infrastructure security and compliance best practices
Required Qualifications
5–7+ years of experience in Site Operations, Site Reliability Engineering, Infrastructure Engineering, or related operational roles
Prior experience leading or mentoring engineering or operations teams
Strong hands-on experience with cloud infrastructure platforms (AWS, Azure, and/or GCP)
Experience managing Kubernetes (K8s) environments in production
Strong understanding of networking concepts including DNS, load balancing, firewalls, routing, and CDN technologies
Experience with Akamai CDN administration and optimization
Experience with observability and monitoring platforms, including Splunk
Experience with storage infrastructure and cloud-native storage solutions
Strong scripting and automation experience (Python, Bash, Terraform, or similar)
Experience implementing and maintaining CI/CD pipelines
Strong troubleshooting and incident management skills in complex distributed systems
Excellent communication and cross-functional collaboration skills
Preferred Qualifications
Experience managing hybrid or multi-cloud environments
Experience with infrastructure-as-code and GitOps methodologies
Familiarity with security best practices and compliance frameworks
Experience supporting highly available enterprise or SaaS platforms
Strong understanding of container security and cloud-native architectures
About Twist Bioscience
Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.
At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.
Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.
The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.
San Francisco Bay Area Pay Range
$210,383—$243,210 USD