Senior Scientist: Bispecifics and Antibody Engineering

Build our future together:
At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a results-driven Senior Scientist to join our Antibody Engineering team within the Bispecifics and Antibody Engineering Department, designing, producing, and characterizing next-generation antibody and protein therapeutics across multiple therapeutic areas with a focus on myeloid cell biology. In this role, your work will directly contribute to the pipeline and help build new platform capabilities at a pivotal time for antibody engineering.
This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.
When & where:
Location: Tarrytown, N
Work model/flexibility: Onsite
Discover your role:
Apply molecular and structural biology expertise to independently design innovative multi-specific antibodies with desired potency, selectivity, and developability
Perform molecular and structural-guided design, high-throughput construct generation, and vector engineering using modern software and tools
Produce and purify novel and logic-gated alternative format antibodies using mammalian expression systems and chromatographic techniques (e.g., AKTA systems)
Characterize binding affinities, binding kinetics, and stability
Design and implement high-throughput biochemical and cell-based assays (e.g., ELISA, AlphaLISA, flow cytometry binding, phagocytic assays, cell activation, and cytolytic assays)
Troubleshoot bioanalytical and cell-based assay data to inform subsequent iterations
Communicate biologic designs and data updates to program stakeholders to meet program objectives
Maintain timely, accurate records using Benchling and research ELN, and clearly convey results during cross-departmental meetings
This role requires:
Ph.D. in molecular biology, cell biology, biochemistry, immunology, or a related field, with at least 1 year of relevant experience in academia or industry
Expertise in myeloid, molecular, and protein biology
Strong organizational, communication, and presentation skills
Ability to quickly learn new skills and troubleshoot antibody production and functional assays effectively
Preferred: hands-on experience with cloning, antibody expression in mammalian cell lines, antibody purification (e.g., using AKTA systems), and comprehensive protein characterization
Preferred: familiarity with cell-free expression and structural AI/ML-based design
Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.
Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.
Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.
As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.
For jobs in Canada: this posting is for an existing position.
Salary Range (annually)
$109,900.00 - $179,300.00