Scientist I, Dermatology/Immunology

AbbVie’s Immunology R&D organization is looking for a highly motivated Scientist I to join our Dermatology Discovery team at the Cambridge Research Center in Cambridge, MA. This researcher will contribute to the identification and validation of novel therapeutics for inflammatory skin diseases. The Dermatology Discovery team applies human disease transcriptomic and multi-omics data sets in combination with wet-bench science to perform mechanistic in vitro studies with the overarching goal to elucidate disease-driving mechanisms that will advance innovative therapeutic strategies. The successful candidate will play a key role in the preclinical research team by conducting in vitro models focusing on human translation to HS and PsO.
The ideal candidate is scientifically curious, collaborative, enthusiastic, skilled, and dedicated. This position requires passion, attention to detail, prior hands-on experience, and teamwork within a fast-paced drug discovery environment.
Key Responsibilities:
Sterile cell culture (cell lines and primary human and murine cells)
Process and analyze ex-vivo human tissues for disease-relevant endpoints
Perform analyses using the following techniques:
Flow cytometry
Quantitative PCR
Protein analyses – ELISA, MSD and multiplex assays
Western blotting
Microscopy
Develop and implement assays that monitor cellular processes
Analyze data using appropriate statistical methods and communicate findings through presentations and scientific discussions
Maintain detailed experimental records and ensure compliance with electronic laboratory notebook
Prior hands-on experience with keratinocytes, fibroblasts, and immune cells (Th17 T cell differentiation, macrophage polarization) is a plus
Candidates with prior experience in complex human in vitro model will receive extra consideration
Bachelor’s degree in molecular biology, immunology or other biological sciences (BS/BA) with 5 years of experience
Master’s degree with 2 years of experience is desired
Key AbbVie Competencies:
Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance
Learns fast, grasps the “essence” and can change course quickly
Raises the bar and is never satisfied with the status quo
Creates a learning environment, open to suggestions and experimentation for improvement
Embraces the ideas of others and nurtures innovation to make possibilities real

Employment type
Full-time

Work arrangement
No