Scientist, Preclinical Pharmacology - Neuroscience & Immunology

Work Your Magic with us! Start your next chapter and join EMD Serono.
Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.
United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.
This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.
Your Role:
EMD Serono is hiring a Scientist II, Preclinical Pharmacology. This position reports to the Principal Scientist / Lab Head and is accountable for the independent scientific execution of in vivo pharmacology studies supporting programs across immunology and inflammation (I&I), neuroscience, fertility and other therapeutic areas. This role contributes to translational PK/PD and biomarker strategies, executes disease-model studies across multiple therapeutic areas, operating with a high degree of technical independence.
Responsibilities:
Scientific & Pharmacology:
Establish, validate, optimize, and troubleshoot fit-for-purpose in vivo disease models — including acute and chronic disease-relevant models — to defined validation milestones and reproducibility criteria
Build and apply immunological and/or neurological disease models to evaluate efficacy, target engagement, pharmacodynamic response, and translational relevance of novel therapeutic approaches, delivering study-ready data packages on schedule and in compliance with protocol and quality standards
In Vivo Pharmacology:
Hands on execution of in vivo pharmacology studies in disease models — including dosing via IV, SC, IP, PO, ICV, and IT routes, blood and CSF sampling, tissue collection, and necropsy — delivering study-ready samples on schedule and in compliance with protocol and quality standards
Perform and support surgical procedures relevant to broad set of pharmacology assays, including but not limited to surgical models, ICV/IT administration, stereotaxic injections, surgical recovery monitoring, and clinical scoring, to define procedural and welfare standards
Support in vivo pharmacology studies by conducting broad, standardized assessments of functional, behavioral, and physiological endpoints across preclinical disease models, enabling robust evaluation of treatment-related effects
Support biomarker strategy execution, including fluid, tissue, molecular, inflammatory, and translatable biomarker readouts
Manage CRO partnerships and external study execution, extending the laboratory’s capacity and geographic reach, ensuring program timelines are maintained without compromising scientific standards
Champion IACUC & AAALAC compliance across the in vivo function
Translational PK/PD and Biomarker Support:
Conduct PK sampling in rodents, including plasma, tissue, and disease-area-relevant matrix collection to support exposure and target engagement assessments
Execute target engagement marker assays, cytokine/chemokine assays, and support histology/IHC coordination and molecular endpoint integration
Who You Are:
Minimum Qualifications:
PhD in Pharmacology, Neuroscience, Immunology, Physiology, or other life science discipline with 4+ years of drug discovery experience in a pharmaceutical or biotech industry setting
OR
Master’s degree in Pharmacology, Neuroscience, Immunology, Physiology, or other life science discipline with 6+ years of drug discovery experience in a pharmaceutical or biotech industry setting
OR