Senior Scientist, Biochemistry

The Senior Scientist, Biochemistry will lead development and implementation of high-throughput biochemical assays to discover and characterize aminopeptidases with properties relevant to next-generation protein sequencing. The role will focus on screening diverse aminopeptidase candidates for activity, selectivity, kinetics, robustness, and performance across a broad range of substrates. The successful candidate will combine strong expertise in enzymology, protein biochemistry, assay development, and quantitative data analysis to advance enzyme reagents.
Core Responsibilities
Develop workflows and progression criteria for primary screening, hit confirmation, characterization, ranking, and advancement of enzyme candidates.
Integrate screening assays into enzyme-evolution pipelines and coordinate the advancement of promising candidates into downstream development and sequencing-assay evaluation.
Develop clear, reusable reporting tools to communicate screening results, candidate recommendations, and pipeline status.
Purify and characterize proteins to support assay development and candidate evaluation.
Use laboratory automation and data-analysis tools to increase screening throughput, consistency, and traceability.
Contribute to a culture of scientific rigor, execution, continuous learning, and knowledge sharing.
Document and transfer selected assays to downstream QC teams to support the release of production enzymes.
Required Qualifications
M.S. with 7+ years or Ph.D. with 3+ years of relevant academic or industry experience in protein biochemistry, enzymology, biophysics, biotechnology, chemical biology, or a related field.
Demonstrated ability to independently and creatively design, optimize, and troubleshoot biochemical assays for challenging enzymology applications.
Strong foundation in enzyme kinetics, protein-substrate interactions, assay controls, and quantitative interpretation of biochemical data.
Experience developing enzyme-activit