Senior Project Manager

The TerraPower Isotopes® (TPI™) division has been established to pursue medical isotopes development--advancing nuclear science for significant human health benefits. We seek to support revolutionary radiotherapies for treatments of various cancers through the supply of radioisotopes. TerraPower currently has unique access to a supply of thorium for the long-term production of actinium-225 in the growing alpha therapy market and intends to expand into other nuclear related medical treatments.
The TerraPower Isotopes program is an integral part of the Washington State based TerraPower team, a company working to raise living standards globally. In 2006, the company originated with Bill Gates and a group of like-minded visionaries who evaluated the fundamental challenges to raising living standards around the world. TerraPower’s mission is to be a world leader in new nuclear technologies, while developing innovators and future leaders in the nuclear field.
TPI is seeking to hire highly motivated and forward-thinking professionals who are interested in focusing on advanced radiopharmaceutical applications and influencing change within nuclear medicine. TerraPower is an Equal Opportunity Employer. We do not discriminate in hiring on the basis of sex, gender identity, sexual orientation, race, color, religious creed, national origin, physical or mental disability, protected veteran status, or any other characteristic protected by federal, state, or local law.
Senior Project Manager, TPI
TerraPower Isotopes® (TPI™) is seeking a Senior Project Manager to serve as TPI’s owner’s project manager for a first-of-a-kind, greenfield cGMP actinium-225 manufacturing facility—a multi-hundred-million-dollar capital program that combines pharmaceutical-grade manufacturing with shielded nuclear containment. Working within the TPI Project Office, this role holds end-to-end delivery accountability for the facility’s scope, schedule, cost, and risk, from design through construction, equipment delivery, commissioning, qualification, and turnover to operations.
This is a senior individual-contributor role for a capital project leader who has delivered complex, regulated facilities from the owner’s side and can act as the single point of accountability across a design-build partner, multiple specialized equipment vendors, and TPI’s internal engineering, quality, operations, and radiation safety teams. The role directs development of the facility design, leads delivery of the shielded containment (hot cell) program, and owns the project controls system—earned value management, integrated master scheduling, cost and contingency control, and change control—against which the program is measured. Success depends on deep technical and commercial judgment, command of project controls, and the ability to lead through influence in an environment where regulatory rigor is non-negotiable.
Responsibilities
Capital Program Leadership
Serve as TPI’s owner’s project manager and single point of accountability for delivery of a greenfield cGMP radiopharmaceutical manufacturing facility, from design development through construction, installation, commissioning, qualification, and handover to operations.
Own the project execution plan, performance measurement baseline, and delivery strategy, and represent the project to TPI executive leadership and board-level stakeholders on status, risk, and funding needs.
Lead a matrixed owner’s team—engineering, quality, operations, radiation safety, supply chain, and contracted specialists—setting priorities and holding deliverable expectations without formal direct reports.
Sequence delivery milestones against radioactive materials licensing, commissioning, qualification, and production start-up requirements, and drive readiness decisions at each project gate.
Design-Build and Contract Management
Serve as TPI’s primary interface with the facility design-builder, administering a lump-sum design-build agreement and associated master services agreements and statements of work, including notices to proceed, allowances, price adjustment mechanisms, pay applications, and contractual notices.
Evaluate contractor change orders, requests for information, and claims for entitlement, cost, and schedule impact, applying recognized methods such as AACE RP 29R-03 (Forensic Schedule Analysis) where delay is asserted; negotiate resolution and protect TPI’s commercial position.
Hold design-build and vendor partners to agreed reporting standards for schedule, cost, progress, and quality, and integrate their data into TPI’s project controls systems.
Facility Design
Drive design of the facility from basis of design through issued-for-construction documents, leading owner design reviews at each design stage, constructability and value-engineering reviews, and design freeze decisions.
Own the owner’s requirements—user requirements, basis of design, and interface control documents—integrating process, architectural, structural, MEP, and HVAC design with cGMP cleanroom classification (ISO 14644-1), contamination control, shielding, and radiological requirements.