Senior Scientist - Oligo Bioinformatics

Work Your Magic with us! Start your next chapter and join EMD Serono.
Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.
United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.
This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.
Your Role:
Are you passionate about translating complex genomic data into life-changing RNA therapeutics? Our Oligonucleotide Therapeutics Group (DDTech) at EMD Serono in Billerica, MA, is expanding, and we are looking for a Senior Scientist in Oligo Bioinformatics to lead the computational design and optimization of our next-generation siRNA and ASO pipelines.
In this role, you will sit at the crucial intersection of computational biology, chemistry, and drug discovery—directly shaping therapeutic programs from target identification through lead optimization. If you thrive in a fast-paced, highly collaborative environment where your algorithms directly inform lab experiments, we want to hear from you.
Responsibilities:
Utilize Bioinformatics platforms to design, evaluate and optimize siRNA and ASO sequences for targeted gene silencing
Analyze gene expression data to identify suitable targets for siRNA/ASO development
Work closely with chemists and biologists to integrate bioinformatics approaches into experimental workflow
Perform transcriptome wide off-target prediction and annotation
Develop pipelines that determine mapping coordinates and homology of oligonucleotides to genomes and transcriptomes
Analyze High through put screening datasets and identify SAR
Who You Are:
Minimum Qualifications:
PhD in Chemistry, Chemical Engineering or other Science or Engineering discipline
3+ years of dedicated experience within the Oligonucleotide field
Preferred Qualifications:
Proficient in Bioinformatics tools and software (e.g. BLAST, Ensemb. RNA fold, siRNA design tools)
Experience with common human genetics resources and techniques
Experience with analyzing large genomic and transcriptomic datasets including RNA seq, Single cell RNA seq, splice isoforms and variant database
Highly collaborative and strong problem-solving ability
Strong organizational skills and ability to manage multiple experiments or project priorities in a fast-paced research environment
Excellent written and verbal communication skills and strong scientific curiosity and innovation mindset
Ability to work effectively in a collaborative, cross-functional team environment