Global Development Medical Director

Job Description
As a Global Development Medical Director, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives. The successful Study Clinical Lead in Late Phase CVRM (Cardiovascular, Renal, and Metabolic diseases) will be responsible for the design, conduct, monitoring, data interpretation and reporting of individual clinical trials ensuring that the clinical data collected within the study will allow determination of the benefits and risks of the compound, as well as will allow for the intended label indication and price in markets globally. The individual will operate according to the highest ethical standards in compliance with internal SOPs, local regulations, laws, Good Clinical Practice, and regulatory requirements.
Responsibilities
Provides strategic medical and scientific knowledge (Cardiovascular, Renal, Metabolic, and/or Hepatic Diseases) and supports the design, initiation, execution, completion, and interpretation of a clinical study
Is accountable for study designs
Is accountable to deliver medical information, answers, and clarifications to Regulators, Ethic Committees, Marketing Companies, Investigators/Sites
Trial conduct and hands-on delivery accountabilities
Is accountable to the Global Clinical Head (GCH) or delegate for the medical aspects and designs of studies
Is responsible for driving decisions within Study Team (ST) remits together with other ST members and for solving medical issues in the study team
Is accountable for the medical and ethical components of studies including patient safety on a study level in compliance with GCP
Is accountable for delivery of the clinical components of all relevant study documents (e.g Protocol, Amendments, Statistical Analysis Plan, Informed Consent Form, Case Report Forms, and Safety and Risk-Based Monitoring Plans)
Is accountable for ensuring that safety surveillance on a study level including the process for Adverse Events (AE)/ Serious AE reporting, the querying of missing/unclear data, the review of blinded safety data, and the escalation to the GCH/Global Safety Physician when needed.
Is medically accountable for international investigator meetings, and supports Marketing Companies (MC) in national activities
Approves (with the GCH) the Clinical Study Report; including preparation and production thereof (Introduction, Results, Discussion).
Is accountable for ST induction and education of new members in the study team, as well as others involved in the study
Collaborates seamlessly and efficiently with global colleagues at other R&D sites
May be accountable to GCH (or delegate) and leadership for identifying risks and proposing mitigation strategies to deliver successful Phase II, III, IV or Life Cycle Management studies
Scientific medical analytical accountabilities
Stays updated on relevant scientific literature
Delivers analyses of clinical data in a balanced, statistically sound fashion, to drive interpretations and further idea generation
Serves as a source of medical expertise for the Product Team, in analyses and interpretation of medical data
Messaging and external impact accountabilities
Maintains a high degree of understanding and awareness on new and emerging medical development, globally.
Works with international colleagues and with external Alliance partners on development initiatives and regulatory issues
Applies strategic intent of AstraZeneca when working with Alliance partners, Regulatory Authorities, payers, opinion leaders, prescribers and consumers of AstraZeneca products
Able to provide guidance for investigator-initiated trials in cooperation with regional marketing companies
Minimum Requirements
Graduate of a recognized school of medicine with an M.B.B.S., M.D. degree or equivalent, and/or a graduate of a scientific doctorate (e.g. PhD or PharmD) or equivalent in a scientific discipline or Pharmaceutical Medicine
3+ years clinical research expertise in relevant therapy area in study design, protocol development, monitoring and implementing clinical trials, interpreting and reporting trial results
Proven teamwork and collaboration skills
Fluent in oral and written English
Good presentation skills and effective communication
A clear demonstration of:
Leadership qualities, with particular focus on collaborative working skills, trust and openness, irrespective of cultural setting
AstraZeneca values and behaviors
Agile responsiveness to scientific data
Credibility in scientific and commercial environments
Desired Experience:
Good general medical knowledge preferably in endocrinology, nephrology, or MASH
Experience of clinical research and clinical expertise in one of our core therapy areas are valued assets
Good knowledge of biostatistics, global regulatory environment and pharmacovigilance
An understanding of pharmaceutical industry R&D, particularly of major clinical milestones and of the factors which influence drug development
An understanding of the interplay between clinical, commercial objectives, drug safety and regulatory requirements
Why AstraZeneca?
Here, we need leadership at every level - leaders who not only have expertise, but also the ability to build a case, engage multiple partners, and communicate effectively with different audiences. Early clinical development is at the forefront of discovery of new medicines for patients with high unmet need. With that kind of remit comes great responsibility. Your curiosity and passion for personal development combined with support from colleagues, mentors and leaders, will ensure you maximize your skills, abilities and contribution. We offer a competitive salary and excellent benefits.
The annual base pay for this position ranges from 249,827.20 - 374,740.80 USD Annual . Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.
Date Posted
08-Sept-2026
Closing Date
15-Sept-2026
Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.