Principal Data Platform Architect

Job Description
At CluePoints, we’re redefining how clinical trials are run. As the premier provider of Risk-Based Quality Management (RBQM) and Data Quality Oversight software, we harness advanced statistics, artificial intelligence, and machine learning to ensure the quality, accuracy, and integrity of clinical trial data, helping life sciences organizations bring safer, more effective treatments to patients faster.
We’re proud to be an ambitious, fast-growing technology scale-up with a dynamic and diverse international team representing more than 20 nationalities. Collaboration, flexibility, and continuous learning are part of our DNA.
At CluePoints, you’ll find a culture where you can grow, make an impact, and have fun along the way. Guided by our values of Care, Passion, and Smart Disruption, we’re united by a shared mission: to create smarter ways to run efficient clinical trials and deliver AI-powered insights that improve human outcomes worldwide.
The Role
We’re looking for a Principal Architect to join our Data Layer squad and contribute to our mission of transforming clinical research through data-driven insights. This is a hands-on, player-coach role: you’ll own the design of the CluePoints data layer and build it with the squad. You’ll report to our GM, with a dotted line to the VP Engineering.
Job Requirements
What You’ll Be Doing
Own the design of the CluePoints data layer and build it hands-on, writing production code alongside the squad.
Design a metadata-driven schema with a stable spine that absorbs change without breaking the applications built on it.
Build a semantic tier that maps study fields to concepts, keeping structure and meaning cleanly separate.
Deliver a versioned, auditable query interface for our applications, with lineage and attributable change built in.
Set the squad’s engineering and AI-first practices, using AI tools with clear verification and evaluation.
Coach engineers through code and design, and partner with our GM and VP Engineering on direction.
Nice to Have
Multi-tenant SaaS experience with strong data segregation.
Familiarity with clinical data, CDISC, or standards such as FHIR, OMOP, and ODM. We’ll help you with the clinical side.
Open-source contributions or talks in data lineage, metadata, or health data interoperability (e.g. OpenLineage, DataHub, Iceberg, HAPI FHIR, OHDSI).
Job Responsibilities
What You’ll Be Doing
Own the design of the CluePoints data layer and build it hands-on, writing production code alongside the squad.
Design a metadata-driven schema with a stable spine that absorbs change without breaking the applications built on it.
Build a semantic tier that maps study fields to concepts, keeping structure and meaning cleanly separate.
Deliver a versioned, auditable query interface for our applications, with lineage and attributable change built in.
Set the squad’s engineering and AI-first practices, using AI tools with clear verification and evaluation.
Coach engineers through code and design, and partner with our GM and VP Engineering on direction.
Job Benefits
What We Offer – Belgium
Health Insurance through Alan (100% hospitalisation cover, 80% ambulatory and dental)
Mobility Budget for eco-transport, housing, or car allowance (flexible 3-pillar system)
Group Insurance Plan with 6–12% employer pension contribution based on seniority
Meal Vouchers (€8/day) and Eco Vouchers for sustainable purchases
A hub-based hybrid model that blends flexibility with purpose — connecting teams through collaboration, learning, and a vibrant social culture.
Equal Opportunities & GDPR Notice
CluePoints is an equal opportunities employer. We value and respect diversity in our workforce and do not tolerate discrimination based on gender, age, disability, ethnic origin, religion, sexual orientation, or any other protected ground under Belgian law.
Personal data collected as part of your application will be processed in compliance with the EU GDPR and Belgian data protection legislation.
You have the right to access, correct, or delete your personal data at any time by contacting privacy@cluepoints.com.
At CluePoints, we believe that diverse teams make better decisions and drive innovation. We’re committed to building a workplace that reflects the communities we serve and where everyone can thrive.

Work arrangement
Yes